Regulation of Sleep and Wakefulness - Revision history

>Mainländr: -Role of GABA and Acetylcholine in combination needs to be elaborated on, -cool model needs to be added, -sources etc

2020-12-26T14:18:56Z

-Role of GABA and Acetylcholine in combination needs to be elaborated on, -cool model needs to be added, -sources etc

← Older revision		Revision as of 14:18, 26 December 2020
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	==Physiology==		==Physiology==
	The underlying physiology of sleep and wakefulness is complex. Different Neurons and Neurotransmitters promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns\|discharge patterns]] and/or [[Transmitter Release\|transmitter release]] and other neurobiological classifications.		The underlying physiology of sleep and wakefulness is complex. Different [[Neurons]] and [[Neurotransmitters]] promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns\|discharge patterns]] and/or [[Transmitter Release\|transmitter release]] and other [[neurobiological classifications]].

	===State-specific discharge patterns===		===State-specific discharge patterns===
	Neurons are classifiable based on their discharge-pattern. During each behavioral state, there are neurons that fire at a higher rate as others. More specifically:		Neurons are classifiable based on their [[discharge-pattern]]. During each behavioral state, there are [[neurons]] that fire at a higher rate as others. More specifically:

	*Wake-On (/REM-Off)		*Wake-On (/REM-Off)
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	===State-specific transmitter secretion===		===State-specific transmitter secretion===
	In neurobiology, neurons are also classified by their state-specific transmitter release.		In neurobiology, neurons are also classified by their [[state-specific transmitter release]].


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	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.

			===== Equations =====
			S(t)

			S(t)

			Ct)

	Advantages:		Advantages:
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	* No physiological basis for Process C and interaction of Process S & C		* No physiological basis for Process C and interaction of Process S & C
	* Does not include [[circadian pacemarkers]] and different [[sleep stages]]		* Does not include [[circadian pacemarkers]] and different [[sleep stages]]

	~~====Model1====~~

	~~====Model2====~~

	~~====Model3====~~

>Mainländr: 10 years later

2020-12-26T13:37:28Z

10 years later

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 [[File:Two-process model of sleep graph.png|thumb|alt=|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]
 The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep  . Process C describes the ~24h circadian framework in which sleep can occur.
 ====Model1====

Admin: /* Two-process model of sleep */

2020-12-26T13:16:03Z

Two-process model of sleep

← Older revision		Revision as of 13:16, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]
			The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.

	====Model1====		====Model1====

Admin: /* Two-process model of sleep */

2020-12-26T13:14:58Z

Two-process model of sleep

← Older revision		Revision as of 13:14, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis ~~link~~) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|~~The sinus-functions set the circadian framework in which~~ sleep ~~can occur. The blue function demonstrates the rising sleep pressure during~~ the day ~~and its decrease during sleep~~.<br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: [https://doi.org/10.1101/09831]]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]

	====Model1====		====Model1====

Admin: /* Two-process model of sleep */

2020-12-26T13:10:33Z

Two-process model of sleep

← Older revision		Revision as of 13:10, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep.<br~~> <nowiki><br></nowiki~~>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: ~~<nowiki>~~https://doi.org/10.1101/09831~~</nowiki>~~]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep.<br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: [https://doi.org/10.1101/09831]]]

	====Model1====		====Model1====

>Mainländr at 13:09, 26 December 2020

2020-12-26T13:09:45Z

← Older revision		Revision as of 13:09, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep. <nowiki><br></nowiki>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: <nowiki>https://doi.org/10.1101/09831</nowiki>]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep.<br> <nowiki><br></nowiki>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: <nowiki>https://doi.org/10.1101/09831</nowiki>]]
	====Model1====		====Model1====

>Mainländr: w

2020-12-26T13:09:12Z

← Older revision		Revision as of 13:09, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep.		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep. <nowiki><br></nowiki>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: <nowiki>https://doi.org/10.1101/09831</nowiki>]]


	Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: <nowiki>https://doi.org/10.1101/09831</nowiki>]]
	====Model1====		====Model1====

>Mainländr: w

2020-12-26T13:08:45Z

← Older revision		Revision as of 13:08, 26 December 2020
Line 48:		Line 48:
	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
	[[File:Two-process model of sleep graph.png\|thumb]]		[[File:Two-process model of sleep graph.png\|thumb\|alt=\|The sinus-functions set the circadian framework in which sleep can occur. The blue function demonstrates the rising sleep pressure during the day and its decrease during sleep.


			Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: <nowiki>https://doi.org/10.1101/09831</nowiki>]]
	====Model1====		====Model1====

>Mainländr: help

2020-12-26T13:03:52Z

help

← Older revision		Revision as of 13:03, 26 December 2020
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	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.
			[[File:Two-process model of sleep graph.png\|thumb]]
	~~In order to visualise the components of the model, the graph of the study "A~~ Two-~~Process Model for Circadian and Sleep-dependent Modulation~~ of ~~Pain Sensitivity" is used~~

	~~https://www.biorxiv.org/content/10.1101/098319v1.full~~

	====Model1====		====Model1====

>Mainländr: w

2020-12-26T12:55:29Z

← Older revision		Revision as of 12:55, 26 December 2020
Line 47:		Line 47:

	====Two-process model of sleep====		====Two-process model of sleep====
	The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) . Process C describes the circadian framework in which sleep can occur.		The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake (Adenosine-alertness hypothesis link) and deacreses during time spent asleep . Process C describes the ~24h circadian framework in which sleep can occur.

			In order to visualise the components of the model, the graph of the study "A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity" is used

			https://www.biorxiv.org/content/10.1101/098319v1.full

	====Model1====		====Model1====