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While caffeine both does induce a number of scientifically validated positive and negative effects on humans for a short time after consumption, withdrawal symptoms are possible in the case of caffeine dependence and are recognized by the ICD-11 and DSM-5.
While caffeine both does induce a number of scientifically validated positive and negative effects on humans for a short time after consumption, withdrawal symptoms are possible in the case of caffeine dependence and are recognized by the ICD-11 and DSM-5.
Caffeine is also shown to reduce time spent in SWS/REM<ref name="ratsCaffeine" /> in rats.
There are large genetically based differences in caffeine clearance time in the body<ref name="adenosine4" />, which might account for anecdotal accounts of varying sensitivity and prolonged effects of caffeine after ingestion.
There are large genetically based differences in caffeine clearance time in the body<ref name="adenosine4" />, which might account for anecdotal accounts of varying sensitivity and prolonged effects of caffeine after ingestion.
<ref name="bev9">{{cite web |url=http://www.elmwoodinn.com/about/caffeine.html |title=Too Easy to be True. De-bunking the At-Home Decaffeination Myth |last=Richardson |first=Bruce |name-list-style=vanc |year=2009 |publisher=Elmwood Inn |access-date=12 January 2012 |url-status=dead |archive-url=https://web.archive.org/web/20111227192924/http://elmwoodinn.com/about/caffeine.html |archive-date=27 December 2011 |df=dmy-all}}</ref>
<ref name="bev9">{{cite web |url=http://www.elmwoodinn.com/about/caffeine.html |title=Too Easy to be True. De-bunking the At-Home Decaffeination Myth |last=Richardson |first=Bruce |name-list-style=vanc |year=2009 |publisher=Elmwood Inn |access-date=12 January 2012 |url-status=dead |archive-url=https://web.archive.org/web/20111227192924/http://elmwoodinn.com/about/caffeine.html |archive-date=27 December 2011 |df=dmy-all}}</ref>
<ref name="rats">{{cite journal |vauthors=Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD |date=February 1984 |title=Adenosine analogs and sleep in rats |url=https://jpet.aspetjournals.org/content/228/2/268.short |journal=Journal of Pharmacology and Experimental Therapeutics |volume=228 |issue=2 |pages=268-274}}</ref>
<ref name="rats">{{cite journal |vauthors=Radulovacki M, Virus RM, Djuricic-Nedelson M, Green RD |date=February 1984 |title=Adenosine analogs and sleep in rats |url=https://jpet.aspetjournals.org/content/228/2/268.short |journal=Journal of Pharmacology and Experimental Therapeutics |volume=228 |issue=2 |pages=268-274}}</ref>
<ref name="ratsCaffeine">{{cite journal |vauthors=Jang H, Jung J, Jang I, Jang K, Kim S, Ha J, Lee M |date=2012 |title=L-theanine partially counteracts caffeine-induced sleep disturbances in rats |url=https://pubmed.ncbi.nlm.nih.gov/22285321/ |journal=Pharmocology, biochemistry, and behavior |volume=101 |issue=2 |doi=10.1016/j.pbb.2012.01.011}}</ref>
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