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From Polyphasic Sleep Wiki
-Role of GABA and Acetylcholine in combination needs to be elaborated on, -cool model needs to be added, -sources etc
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==Physiology==
 
==Physiology==
The underlying physiology of sleep and wakefulness is complex. Different Neurons and Neurotransmitters promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns|discharge patterns]] and/or [[Transmitter Release|transmitter release]] and other neurobiological classifications.
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The underlying physiology of sleep and wakefulness is complex. Different [[Neurons]] and [[Neurotransmitters]] promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns|discharge patterns]] and/or [[Transmitter Release|transmitter release]] and other [[neurobiological classifications]].
    
===State-specific discharge patterns===
 
===State-specific discharge patterns===
Neurons are classifiable based on their discharge-pattern. During each behavioral state, there are neurons that fire at a higher rate as others. More specifically:
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Neurons are classifiable based on their [[discharge-pattern]]. During each behavioral state, there are [[neurons]] that fire at a higher rate as others. More specifically:
    
*Wake-On (/REM-Off)
 
*Wake-On (/REM-Off)
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===State-specific transmitter secretion===
 
===State-specific transmitter secretion===
In neurobiology, neurons are also classified by their state-specific transmitter release.
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In neurobiology, neurons are also classified by their [[state-specific transmitter release]].
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[[File:Two-process model of sleep graph.png|thumb|alt=|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]
 
[[File:Two-process model of sleep graph.png|thumb|alt=|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]
 
The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep  . Process C describes the ~24h circadian framework in which sleep can occur.
 
The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep  . Process C describes the ~24h circadian framework in which sleep can occur.
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===== Equations =====
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S(t)
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S(t)
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Ct)
    
Advantages:
 
Advantages:
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* No physiological basis for Process C and interaction of Process S & C
 
* No physiological basis for Process C and interaction of Process S & C
 
* Does not include [[circadian pacemarkers]] and different [[sleep stages]]
 
* Does not include [[circadian pacemarkers]] and different [[sleep stages]]
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====Model1====
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====Model2====
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====Model3====
 
confirmed, translator
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