Changes

==Physiology==

==Physiology==

The underlying physiology of sleep and wakefulness is complex. Different Neurons and Neurotransmitters promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns|discharge patterns]] and/or [[Transmitter Release|transmitter release]] and other neurobiological classifications.

The underlying physiology of sleep and wakefulness is complex. Different [[Neurons]] and [[Neurotransmitters]] promote different states of sleep and wakefulness. They are therefore categorised based on state-specific [[Discharge Patterns|discharge patterns]] and/or [[Transmitter Release|transmitter release]] and other [[neurobiological classifications]].

===State-specific discharge patterns===

===State-specific discharge patterns===

Neurons are classifiable based on their discharge-pattern. During each behavioral state, there are neurons that fire at a higher rate as others. More specifically:

Neurons are classifiable based on their [[discharge-pattern]]. During each behavioral state, there are [[neurons]] that fire at a higher rate as others. More specifically:

*Wake-On (/REM-Off)

*Wake-On (/REM-Off)

===State-specific transmitter secretion===

===State-specific transmitter secretion===

In neurobiology, neurons are also classified by their state-specific transmitter release.

In neurobiology, neurons are also classified by their [[state-specific transmitter release]].

[[File:Two-process model of sleep graph.png|thumb|alt=|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]

[[File:Two-process model of sleep graph.png|thumb|alt=|Graph of activity level of sleep processes over the course of a day. <br>Source: Natalia T., Megan H. H., Paige F., Victoria B. (2017). A Two-Process Model for Circadian and Sleep-dependent Modulation of Pain Sensitivity doi: https://doi.org/10.1101/09831]]

The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep  . Process C describes the ~24h circadian framework in which sleep can occur.

The two-process model of sleep is a conceptual model that aims to relate the behavioral state regulation to two main procedures. Process-S describes the increasing homeostatic pressure, the more time spent awake ([[Adenosine-alertness hypothesis]]) and deacreses during time spent asleep  . Process C describes the ~24h circadian framework in which sleep can occur.

Advantages:

Advantages:

* No physiological basis for Process C and interaction of Process S & C

* No physiological basis for Process C and interaction of Process S & C

* Does not include [[circadian pacemarkers]] and different [[sleep stages]]

* Does not include [[circadian pacemarkers]] and different [[sleep stages]]